Anonymous asked this question on 4/26/2000:

What is antihistamine is safe to take with Wellbutrin? (without causing drowsiness)

desertphile gave this response on 4/30/2000:

Please note that I am not a doctor.

Some of the first anti-depressants actually were antihistamines. The "amines" in the word are the neural transmitters that work in a person's central nervous system between the synapses such as serotonin, dopamine, and norepinephrine. The anti-histamines work on the latter amine (mostly), just as the earlier anti-depressants did. Now days the anti-depressants work on the serotonin levels by inhibiting the enzimatic destruction of the amine (slows down the "reuptake" of the amine).

That is why many anti-depressants also dry out one's mouth by the way: they can act like an anti-histamine.

You will find that the majority of anti-histamines are safe with the majority of anti-depressants. The most common side effect would be sleeplessness and "jittery" arms and legs. If you have taken too much anti-histamine, your legs might feel the uncontrollable need to jump and kick while you are laying down. It is very unplesant and can last for hours.

The over-the-counter anti-histamines often include pseudonepherine which molecularly looks close enough to the norpinepherine amine that it will try to act like the amine in the synapse and thus "block" (get in the way of) the actual amine.

Pharmacists not only are generally required to answer your questions about drug interactions--- the majority like to! I noticed they often take plesure in showing off their knowledge. The newer pharmacies have computerized cash registers that actually automatically print out adverse drug interactions. So if you have concerns, please ask a professional.

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